Voltage-gated sodium channels (VGSCs) play an important role in action potential generation and propagation and mediate the rapid influx of sodium ions that underlies the rising phase of the action potential in sensory nociceptive neurons (Blair and Bean, 2002). The Na+ channels, Nav1.3 and Nav1.7, together with Nav1.8 and Nav1.9, have been highlighted as significant molecular targets for the design of low MW blockers for the treatment of chronic pain. The Nav1.8 channel is highly expressed by small primary sensory neuronsand is closely related to the occurrence and development of various types of pain, such as inflammatory pain, neuropathic pain, and inflammatory pain. With Vx-548 reaching its effective endpoint in Phase II clinical practice, the Nav1.8 target has become a popular target for non addictive analgesics. The EPhys team in ICE has validated patch clamp method for human- and rat-derived Nav1.8 cell lines and action potentials (AP) of dorsal root ganglion neurons for drug screening.
膜片钳检测服务|Nav1.8(VX-548)|NaV1.8抑制剂|药物筛选服务
作者:北京爱思益普生物科技股份有限公司 2024-02-28T00:00 (访问量:28497)
北京爱思益普生物科技股份有限公司 商家主页
地 址: 北京市经济技术开发区科创十三街18号院16号楼
联系人: 蔡世伟
电 话: 010-67809840,18513687260
传 真: 010-67809840
Email:caisw@ice-biosci.com
相关咨询
蛋白活性检测实验|蛋白定制组学服务|高活性重组蛋白|爱思益普 (暂无发布时间 浏览数:2200)
药物靶点验证开发|蛋白表达纯化实验|高活性蛋白产品购买 (暂无发布时间 浏览数:2223)
蛋白纯化表达服务|蛋白定制组学服务|蛋白定制化服务|爱思益普 (暂无发布时间 浏览数:1650)
高浓度蛋白产品现货购买|蛋白产品定制化服务|高标准品质蛋白产品 (暂无发布时间 浏览数:1667)
蛋白纯度活性检测实验|蛋白表达纯化实验|蛋白产品定制化服务 (暂无发布时间 浏览数:1629)
蛋白表达服务|高活性蛋白产品|蛋白定制服务|酶学实验检测服务 (暂无发布时间 浏览数:1681)
高品质标准蛋白产品|高浓度蛋白产品|蛋白定制组学服务|爱思益普 (暂无发布时间 浏览数:1711)
高浓度蛋白产品购买|蛋白定制化实验服务|蛋白产品定制服务 (暂无发布时间 浏览数:1660)
蛋白纯度活性检测服务|蛋白表达纯化实验|高活性蛋白产品购买 (暂无发布时间 浏览数:1647)
蛋白纯化实验服务|蛋白活性检测服务|蛋白产品现货购买|爱思益普 (暂无发布时间 浏览数:1645)